Biotin and derivatives
Medchemexpress LLC Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) | 138529-46-1 | 98.0% | 1 G
Biotin-DADOO is an amine compound that contains biotin and functions as a biotinylation reagent. It acts as an amino component, involved in the nucleophilic ring-opening reaction of epoxidized ω-double bonds during the synthesis of biotinylated inhibitor derivatives. This reagent can be conjugated with carboxymethyl cellulose derivatives and is utilized in the synthesis of biotin-estradiol conjugates for enzyme immunoassays. It also finds application in influenza A research.
- Functions as a biotinylation reagent.
- Participates in nucleophilic ring-opening reactions during biotinylated inhibitor synthesis.
- Can be conjugated with carboxymethyl cellulose derivatives.
- Involved in the synthesis of biotin-estradiol conjugates for enzyme immunoassays.
- Used in influenza A research.
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 1 G
endo-BCN-NHS carbonate is an NHS carbonate reagent that installs a bicyclo[6.1.0]non-4-ynyl (BCN) strained alkyne onto primary amines, forming carbamate linkages. The BCN handle enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) for efficient bioconjugation of proteins, peptides, and polymers, and is commonly used to functionalize biomolecules for hydrogel cross-linking and cell-encapsulation studies.
- Reacts with primary amines to form stable carbamate linkages.
- Provides a strained alkyne handle for copper-free SPAAC bioconjugation.
- Enables efficient functionalization of proteins, peptides, and polymers.
- Facilitates hydrogel cross-linking and cell encapsulation applications.
- Supplied as a high-purity solid suitable for research use.
Medchemexpress LLC NSP-SA-NHS | 199293-83-9 | 99.65% | 50 MG
NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed.
- Application: Chemiluminescent immunoassay.
- Specific use: Developed for a rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA).
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 100 MG
M-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC 5-Carboxyfluorescein diacetate N-succinimidyl ester 150206-05-6 10mg
5-Carboxyfluorescein diacetate N-succinimidyl ester (CAS 150206-05-6) is a fluorescent cell-permeable dye It is designed to enable stable cell labeling by facilitating intracellular conversion and covalent attachment to cellular amines 5-Carboxyfluorescein diacetate N-succinimidyl ester exerts its activity through membrane permeation intracellular esterase-mediated cleavage of acetate groups and subsequent covalent coupling to intracellular targets resulting in persistent fluorescence through cell division Based on these properties 5-Carboxyfluorescein diacetate N-succinimidyl ester holds research potential in tracking lymphocyte migration analyzing cell proliferation and investigating cell dynamics and interactions in various in vitro and in vivo experimental models
Apexbio Technology LLC HyperFluor™ 555 NHS Ester 1mg
HyperFluor 555 NHS Ester is a fluorescent labeling reagent targeting primary amines (R NH ) on biomolecules It is designed to facilitate covalent conjugation with proteins amine-modified oligonucleotides and other primary amine-containing biomolecules via its NHS ester moiety HyperFluor 555 NHS Ester exerts its activity through amine-specific covalent labeling Based on these properties HyperFluor 555 NHS Ester holds research potential in fluorescence microscopy and flow cytometry for labeling and detection of proteins and oligonucleotides
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 99.9% | 500 MG
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker primarily used in the synthesis of PROTACs. It also serves as a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker
- PROTAC linker for targeted protein degradation
- Cleavable ADC linker
- Utilizes the ubiquitin-proteasome system
- Suitable for PROTACs synthesis
- Suitable for ADC synthesis
Medchemexpress LLC (+)-Biotin-SLC | 1864003-57-5 | ≥97.0% | 500 MG
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker. It can be used in the synthesis of PROTACs, which are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system
- PROTACs selectively degrade target proteins
- For research use only
Medchemexpress LLC Biotin-azide | 908007-17-0 | 99.84% | 500 MG
Biotin-azide is a form of biotin with a terminal azide group, designed for Click Chemistry applications. It enables the preparation of various biotinylated conjugates through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent has been used in vitro for post-crosslinking chemical functionalization to isolate transcriptional protein complexes from yeast cells.
- Used in Click Chemistry to prepare biotinylated conjugates.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Applied in post-crosslinking chemical functionalization to isolate transcriptional protein complexes.
Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | MFCD21363308 | 98.0% | C26H50N4O9S | 10MG
Biotin-PEG7-amine is a PEG-based biotinylation reagent containing a seven-unit polyethylene glycol spacer terminating in a primary amine. It is used as a linker in PROTAC synthesis and for bioconjugation to introduce a biotin tag for affinity capture and detection.
- PEG7 spacer improves solubility and reduces steric hindrance.
- Terminal primary amine enables coupling to activated carboxyl groups or NHS esters.
- Biotin tag allows efficient affinity capture using streptavidin or avidin systems.
- Compatible with standard peptide- and small-molecule coupling chemistries.
- High purity supports synthetic and analytical applications.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1 G
Bis-PEG21-NHS ester is a versatile PEG/Alkyl/ether-based linker. It serves as a PROTAC linker for the synthesis of PROTACs, which are compounds designed to recruit target proteins to E3 ubiquitin ligases for degradation. Additionally, this molecule functions as a cleavable ADC linker, essential for the construction of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker structure
- Enables synthesis of PROTACs
- Functions as a cleavable ADC linker
- For research use only
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
Medchemexpress LLC Biotin-PEG4-OH | 1217609-84-1 | 98.0% | 100 MG
Biotin-PEG4-OH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It is intended for research use only and is not sold to patients.
- Molecular weight of 419.54
- Molecular formula of C18H33N3O6S
- Appears as a solid
- Color is white to off-white
- Purity is 98.0%
- Identified for laboratory chemicals and manufacturing
- Stable under recommended storage conditions
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29 | 10 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups separated by a PEG21 spacer. It is supplied as a high-purity reagent for bioconjugation, PROTAC synthesis, and antibody-drug conjugate construction.
- Two NHS ester reactive groups for amine coupling.
- PEG21 spacer provides hydrophilicity and flexibility.
- High purity suitable for conjugation chemistry applications.
- Intended for PROTAC and ADC linker development and general PEGylation chemistry.
- Available in small-scale quantities for research use.